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Emerging Imaging Biomarkers in Crohn Disease
Octavia Bane1,2, Michael S Gee3, Alex Menys4,5
1BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Quantitative magnetic resonance imaging (MRI) biomarkers enhance Crohn disease diagnosis and treatment monitoring. Multiparametric MRI offers valuable insights but requires further validation for clinical use.
Area of Science:
- Radiology
- Gastroenterology
- Biomarkers
Background:
- Crohn disease diagnosis and management rely on imaging.
- Magnetic resonance imaging (MRI) offers non-invasive assessment.
- Quantitative biomarkers can improve diagnostic accuracy and treatment evaluation.
Purpose of the Study:
- To review the latest advancements in quantitative MRI biomarkers for Crohn disease.
- To assess the role of these biomarkers in diagnosis, therapy response, and prognosis.
- To discuss limitations and future directions of quantitative MRI in Crohn disease.
Main Methods:
- Literature search of clinical and translational research.
- Inclusion of diffusion-weighted MRI (DWI-MRI), dynamic contrast-enhanced MRI (DCE-MRI), motility MRI, magnetization transfer MRI.
- Integration of emerging techniques like T1 mapping, radiomics, and artificial intelligence.
Main Results:
- Quantitative MRI biomarkers significantly enhance magnetic resonance enterography (MRE) qualitative assessments.
- Substantial diagnostic performance achieved (area under the curve = 0.8-0.95).
- Multiparametric quantitative MRI provides rich data for diagnosis, severity assessment, prognostication, and treatment response evaluation.
Conclusions:
- Quantitative MRI biomarkers add significant value to MRE for Crohn disease management.
- Combining multiple MRI sequences offers comprehensive insights.
- Further validation is needed before widespread clinical adoption and use in drug trials.
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