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[Herpes Simplex Virus Infection in Two Premature Infants - Diagnostic and Therapeutic Management]

Roland Haase1,2, Gregor Seliger3, Jan Baier1

  • 1Abteilung für Neonatologie und Pädiatrische Intensivmedizin, Universitätsklinikum Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland.

Zeitschrift Fur Geburtshilfe Und Neonatologie
|February 2, 2021
PubMed

Insights

Neonatal herpes simplex virus (HSV) infections pose significant risks, particularly for premature infants. Early diagnosis and treatment with acyclovir are crucial for managing these severe systemic infections.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Virology

Background:

  • Neonatal herpes simplex virus (HSV) infections are rare but severe, carrying high morbidity and mortality rates, especially when treatment is delayed.
  • Premature infants are especially vulnerable due to immature immune systems.
  • Symptoms of neonatal HSV can mimic other serious conditions like sepsis, complicating diagnosis.

Purpose of the Study:

  • To present two cases of premature infants with systemic HSV infections.
  • To discuss the diagnostic and therapeutic management strategies for neonatal HSV.
  • To highlight the importance of timely intervention in improving outcomes.

Main Methods:

  • Case report of two premature infants diagnosed with systemic HSV infections.
  • Review of diagnostic approaches, including patient history and specific tests.
  • Description of treatment protocols involving intravenous and enteral acyclovir.

Main Results:

  • Both infants presented with systemic HSV infections.
  • Successful treatment was achieved using intravenous acyclovir followed by suppressive enteral therapy.
  • The cases underscore the need for prompt diagnosis and management.

Conclusions:

  • Systemic HSV infections in premature neonates require vigilant diagnosis and prompt treatment.
  • Intravenous and subsequent enteral acyclovir therapy is an effective management strategy.
  • Early intervention is critical to mitigate the high risks associated with neonatal HSV.

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