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Updated: Nov 19, 2025

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes
Published on: January 10, 2022
Adaptation of bacteria to glyphosate: a microevolutionary perspective of the enzyme
Miia J Rainio1, Suvi Ruuskanen1, Marjo Helander1
1Department of Biology, University of Turku, Turku, Finland.
Abstract:
Glyphosate is the leading herbicide worldwide, but it also affects prokaryotes because it targets the central enzyme (5-enolpyruvylshikimate-3-phosphate, EPSP) of the shikimate pathway in the synthesis of the three essential aromatic amino acids in bacteria, fungi and plants. Our results reveal that bacteria may easily become resistant to glyphosate through changes in the 5-enolpyruvylshikimate-3-phosphate synthase active site. This indicates the importance of examining how glyphosate affects microbe-mediated ecosystem functions and human microbiomes.
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