Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

5.1K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.1K
The Stanford Prison Experiment03:20

The Stanford Prison Experiment

24.1K
The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
24.1K
Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

6.0K
The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
6.0K
The Muscular System01:18

The Muscular System

6.0K
The muscular system is essential to the body's overall structure and function, playing a crucial role in movement, stability, and internal processes. It consists of three distinct types of muscle tissue: the skeletal, the smooth, and the cardiac muscles.
6.0K
Mechanical Systems01:22

Mechanical Systems

403
Mechanical systems are analogous to to electrical networks where springs and masses play similar roles to inductors and capacitors, respectively. A viscous damper in mechanical systems functions similarly to a resistor in electrical networks, dissipating energy. The forces acting on a mass in such systems include an applied force in the direction of motion, counteracted by forces from the spring, a viscous damper, and the mass's acceleration. This interplay of forces is mathematically...
403
Personal Protective Equipment01:20

Personal Protective Equipment

2.0K
Personal protective equipment (PPE) is unique clothing or equipment worn by an employee to minimize or prevent exposure to infectious agents. PPE creates a barrier between the employee and the infectious materials. PPE must be readily available in the patient care area. PPE includes gloves, gowns and aprons, masks and respirators, goggles, face shields, shoes, and headcovers:
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Switching Biologics in Severe Asthma: Cautionary Lessons from NIMBLE.

American journal of respiratory and critical care medicine·2026
Same author

Severe asthma and remission prospects in Europe (SHARP): insights from a multicentre observational study based on the European Severe Asthma Registry.

The Lancet. Respiratory medicine·2026
Same author

The AIM4 Next Step study: Comparing inhaled corticosteroid dose escalation to dupilumab in patients with uncontrolled asthma and type 2 inflammation.

The journal of allergy and clinical immunology. Global·2026
Same author

Educational Intervention on Environmentally Responsible Inhaler Prescribing Among French General Practitioners: Pilot Pre-Post Study.

JMIR formative research·2026
Same author

Complex interplay between disease and aerobic exercise training on vascular function in an exacerbated emphysema rat model.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Reply to Zhao et al.: Clarifying Structural - Functional Coupling by FeNO Status in VESTIGE.

American journal of respiratory and critical care medicine·2026
Same journal

The epidemiological burden and societal cost of 14 respiratory conditions in the World Health Organization European region: systematic evidence map and economic analysis.

ERJ open research·2026
Same journal

Menthol inhalation relieves dyspnoea through the brain.

ERJ open research·2026
Same journal

Understanding the perceptions and experiences of adults with early-onset neuromuscular disorders using noninvasive ventilation in making healthcare decisions.

ERJ open research·2026
Same journal

Exploring glucocorticoid receptor signalling in lymphangioleiomyomatosis.

ERJ open research·2026
Same journal

Senescence intensifies bleomycin-induced injury in idiopathic pulmonary fibrosis lung epithelial cells.

ERJ open research·2026
Same journal

Absolute and relative intensity of physical activity after lung cancer surgery.

ERJ open research·2026
See all related articles

Related Experiment Video

Updated: Nov 19, 2025

Author Spotlight: Development of an Automated Camera-Based System for Real-Time Blast Overpressure Monitoring and TBI Risk Assessment in Military Training
06:20

Author Spotlight: Development of an Automated Camera-Based System for Real-Time Blast Overpressure Monitoring and TBI Risk Assessment in Military Training

Published on: December 6, 2024

3.1K

The six million dollar man.

Mathilde Volpato1, Stefan Nowak1, Jean Luc Bourrain1

  • 1Dept of Respiratory Diseases, University of Montpellier, Montpellier, France.

ERJ Open Research
|February 3, 2021
PubMed
Summary
This summary is machine-generated.

Urticaria relapsed after switching from omalizumab to mepolizumab, indicating that a combination of biologics may be necessary for treatment. This case highlights potential therapeutic strategies for severe chronic urticaria.

More Related Videos

Development of a Novel Task-oriented Rehabilitation Program using a Bimanual Exoskeleton Robotic Hand
06:44

Development of a Novel Task-oriented Rehabilitation Program using a Bimanual Exoskeleton Robotic Hand

Published on: May 20, 2020

7.3K
Adaptation of a Haptic Robot in a 3T fMRI
08:16

Adaptation of a Haptic Robot in a 3T fMRI

Published on: October 4, 2011

10.0K

Related Experiment Videos

Last Updated: Nov 19, 2025

Author Spotlight: Development of an Automated Camera-Based System for Real-Time Blast Overpressure Monitoring and TBI Risk Assessment in Military Training
06:20

Author Spotlight: Development of an Automated Camera-Based System for Real-Time Blast Overpressure Monitoring and TBI Risk Assessment in Military Training

Published on: December 6, 2024

3.1K
Development of a Novel Task-oriented Rehabilitation Program using a Bimanual Exoskeleton Robotic Hand
06:44

Development of a Novel Task-oriented Rehabilitation Program using a Bimanual Exoskeleton Robotic Hand

Published on: May 20, 2020

7.3K
Adaptation of a Haptic Robot in a 3T fMRI
08:16

Adaptation of a Haptic Robot in a 3T fMRI

Published on: October 4, 2011

10.0K

Area of Science:

  • Immunology
  • Dermatology
  • Allergy and Clinical Immunology

Background:

  • Chronic spontaneous urticaria (CSU) is a debilitating condition often refractory to standard therapies.
  • Biologic agents like omalizumab and mepolizumab target key inflammatory pathways in CSU.
  • Treatment decisions involve balancing efficacy, safety, and patient response.

Purpose of the Study:

  • To report a case of CSU relapse after switching from omalizumab to mepolizumab.
  • To explore the potential benefit of combining biologics in refractory CSU.
  • To contribute to understanding treatment algorithms for severe CSU.

Main Methods:

  • A case report detailing a patient with CSU.
  • Description of treatment history including omalizumab and mepolizumab.
  • Observation of clinical response and relapse following medication switch.

Main Results:

  • The patient experienced a relapse of urticaria symptoms after discontinuation of omalizumab and initiation of mepolizumab.
  • Subsequent combination therapy with both biologics led to successful disease control.
  • This suggests a potential synergistic effect or the need for dual pathway inhibition.

Conclusions:

  • Switching biologics in CSU may lead to relapse, necessitating careful consideration of treatment strategies.
  • Combination therapy with omalizumab and mepolizumab can be effective in managing refractory CSU.
  • Further research is warranted to evaluate the efficacy and safety of combined biologic approaches in CSU.