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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Interleukin-1β, Oxidative Stress, and Abnormal Calcium Handling Mediate Diabetic Arrhythmic Risk

Hong Liu1, Yang Zhao2, An Xie1

  • 1Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.

JACC. Basic to Translational Science
|February 3, 2021
PubMed

Keywords:
APD, action potential durationDM, diabetes mellitusEAD, early afterdepolarizationIL, interleukinIL-1RA, interleukin-1 receptor antagonistIto, transient outward potassium currentRyR2, ryanodine receptorSR, sarcoplasmic reticulumT1DM, type 1 diabetes mellitusT2DM, type 2 diabetes mellitusVT, ventricular tachycardiacalcium handlinginflammationmitoROS, mitochondrial reactive oxygen speciesmitochondriaoxidationsudden cardiac death

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