Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Behavioral interactions between nicotine and caffeine.

J M White1

  • 1Department of Psychology, Monash University, Clayton, Victoria, Australia.

Pharmacology, Biochemistry, and Behavior
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Successful use of vincristine in a quarter horse gelding with immune-mediated thrombocytopenia.

Journal of equine veterinary science·2026
Same author

Corrigendum to "Missed opportunities: The unknown impact of the COVID-19 pandemic on early childhood development in the WHO European region" [Pub. Health Practice 10 (2025) 100636].

Public health in practice (Oxford, England)·2026
Same author

Missed opportunities: The unknown impact of the COVID-19 pandemic on early childhood development in the WHO European region.

Public health in practice (Oxford, England)·2025
Same author

High-Frequency Basal Cell Carcinoma: Demographic, Clinical, and Histopathological Features in a Belgian Cohort.

Journal of clinical medicine·2025
Same author

Hidradenitis suppurativa patients over 50 years old differ significantly from younger patients.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Risk Factors and Innovations in Risk Assessment for Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma.

Cancers·2024
Same journal

Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

Pharmacology, biochemistry, and behavior·2026
Same journal

Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

Pharmacology, biochemistry, and behavior·2026
Same journal

Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

Pharmacology, biochemistry, and behavior·2026
Same journal

Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

Pharmacology, biochemistry, and behavior·2026
Same journal

Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

Pharmacology, biochemistry, and behavior·2026
Same journal

Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

Pharmacology, biochemistry, and behavior·2026
See all related articles

Nicotine and caffeine interact in complex ways to affect rat behavior. Caffeine can enhance or block nicotine

Area of Science:

  • Pharmacology
  • Behavioral Neuroscience

Background:

  • Nicotine and caffeine are widely consumed psychoactive substances.
  • Both substances individually affect operant behavior.

Purpose of the Study:

  • To investigate the combined effects of nicotine and caffeine on rat behavior.
  • To examine dose-dependent interactions between nicotine and caffeine.

Main Methods:

  • Rats were trained on a fixed-interval 2-min schedule of food reinforcement.
  • Nicotine and varying doses of caffeine were administered alone and in combination.
  • Response rates and within-interval patterns were analyzed.

Main Results:

  • Low-dose caffeine (3.0 mg/kg) potentiated nicotine's effect on response rate.

Related Experiment Videos

  • Higher caffeine doses (10.0 and 30.0 mg/kg) reduced or abolished nicotine-induced increases in response rate.
  • Both drugs affected within-interval responding similarly, with additive effects at high doses.

    • Conclusions:

    • The interaction between nicotine and caffeine is complex and dose-dependent.
    • The specific behavioral measure influences the observed interaction.
    • Co-administration can lead to significant alterations in response patterns.