Related Experiment Video
Updated: Nov 18, 2025

Simplified, High-throughput Analysis of Single-cell Contractility using Micropatterned Elastomers
Published on: April 8, 2022
Health and Fitness at the Single-Cell Level
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee. douglas.green@stjude.org.
Abstract:
Genetically identical cells in a tissue can respond differently to perturbations in their environment or "stress." Such stresses can be physicochemical, mechanical, or infectious or may come from competition with other cells in the tissue. Here, I discuss how the varying responses to stress influence the decision of a cell to repair or die, and how one cell's response can have effects on surrounding cells. Such responses control the health and fitness of single cells and how they compete with other genetically identical cells.See related article on p. 129.
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