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Intracellular Movement of Viruses and Bacteria01:10

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Updated: Nov 18, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

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Herpes Simplex Virus Cell Entry Mechanisms: An Update.

Krishnaraju Madavaraju1, Raghuram Koganti1, Ipsita Volety1

  • 1Shukla Lab, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States.

Frontiers in Cellular and Infection Microbiology
|February 4, 2021
PubMed
Summary
This summary is machine-generated.

Herpes simplex virus (HSV) entry into host cells involves surface glycoproteins binding receptors and membrane fusion. Blocking this crucial fusion step offers a promising antiviral strategy against HSV infections.

Keywords:
HSVendocytosisentryherpesvirusmechanism

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Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Herpes simplex virus (HSV) infects diverse hosts, causing varied human illnesses.
  • HSV surface glycoproteins mediate host cell attachment and fusion, a critical step for infection.
  • Viral entry pathways include pH-dependent and independent endocytosis.

Purpose of the Study:

  • To review HSV entry mechanisms.
  • To explore cell-to-cell spread of HSV.
  • To discuss viral glycoproteins as potential antiviral targets.

Main Methods:

  • Literature review of viral entry pathways.
  • Analysis of HSV glycoprotein functions.
  • Examination of antiviral strategies targeting viral entry.

Main Results:

  • HSV utilizes conserved glycoproteins to bind host cell receptors.
  • Viral fusion with the host membrane is essential for nucleocapsid delivery.
  • Blocking fusion presents a viable strategy to inhibit HSV infection.

Conclusions:

  • Understanding HSV entry mechanisms is key to developing effective antivirals.
  • Targeting viral glycoproteins can prevent HSV cell entry and subsequent pathogenesis.
  • Inhibiting HSV fusion offers a promising therapeutic approach.