Biventricular Longitudinal Strain Predict Mortality in COVID-19 Patients
Yuji Xie1,2, Lufang Wang1,2, Meng Li1,2
1Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in Cardiovascular Medicine
|February 4, 2021
Summary
Biventricular longitudinal strain, including left and right ventricular measures, predicts mortality in COVID-19 patients. Impaired strain indicates higher risk, while improvement suggests recovery, aiding in risk stratification.
Area of Science:
- Cardiology
- Infectious Diseases
- Echocardiography
Background:
- Biventricular longitudinal strain is a known predictor of adverse outcomes in cardiovascular diseases.
- The prognostic value of biventricular longitudinal strain in coronavirus disease 2019 (COVID-19) remains under investigation.
Purpose of the Study:
- To evaluate the prognostic significance of biventricular longitudinal strain in patients diagnosed with COVID-19.
- To determine if left ventricular global longitudinal strain (LV GLS4CH) and right ventricular free wall longitudinal strain (RV FWLS) can predict mortality in COVID-19.
Main Methods:
- 132 consecutive patients with COVID-19 were analyzed.
- Two-dimensional speckle-tracking echocardiography was used to measure LV GLS4CH and RV FWLS.
- Correlation with inflammatory biomarkers, coagulopathy, and clinical outcomes including mortality was assessed.
Main Results:
- Patients with cardiac injury showed decreased LV GLS4CH and RV FWLS, elevated inflammatory markers, and higher mortality.
- Impaired LV GLS4CH and RV FWLS were significantly associated with increased mortality during hospitalization.
- LV GLS4CH and RV FWLS demonstrated significant improvement at 3-month follow-up in survivors.
Conclusions:
- LV GLS4CH and RV FWLS are independent predictors of mortality in COVID-19 patients.
- Biventricular longitudinal strain measurements are valuable for risk stratification and monitoring recovery in COVID-19.
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