Biomedical applications of methionine-based systems.

Area of Science:

• Biomedical Science
• Amino Acid Metabolism
• Therapeutic Strategies

Background:

• Methionine (Met) is an essential amino acid with unique chemical and metabolic characteristics.
• Its derivatives, like S-adenosylmethionine (SAM), play crucial roles in biological processes.
• Met's properties offer significant potential for diverse biomedical applications.

Purpose of the Study:

• To systematically review recent advancements in methionine-based strategies for biomedical applications.
• To explore Met's potential in cancer treatment, diagnosis, and liver disease therapy.
• To analyze current challenges and future trends, including Met-restriction therapy for COVID-19.

Main Methods:

• Review of recent scientific literature on methionine's chemical modifications and metabolic pathways.
• Detailed summary of Met's applications in cancer treatment and diagnosis.
• Discussion of S-adenosylmethionine (SAM) efficacy in treating liver diseases.

Main Results:

• Two chemical modification methods for Met are introduced.
• Met shows significant potential in cancer treatment and diagnosis due to tumor cell metabolic alterations.
• S-adenosylmethionine (SAM) demonstrates efficacy in treating liver diseases.

Conclusions:

• Methionine holds immense potential for various biomedical applications.
• Met-restriction therapy is proposed as a promising approach for COVID-19 treatment.
• Further research is needed to overcome current challenges and fully exploit Met's therapeutic capabilities.