Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 15, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Electrospun aligned nanofibers for tissue engineering.

Gayatri Patel1, Nasim Annabi2, Louis-S Bouchard3,4,5

  • 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.

Biomaterials Science
|July 14, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Weak solutions to the Bloch equations with distant dipolar field.

The Journal of chemical physics·2026
Same author

Biocompatible, Ion-Conductive Hydrogel-Filled Nerve Conduit for Peripheral Nerve Regeneration.

ACS applied materials & interfaces·2026
Same author

Chirality-encoded molecular wavefunctions.

The Journal of chemical physics·2025
Same author

Emerging innovations in 3D and 4D bioprinting.

Biomaterials science·2025
Same author

A Synthetic Phage-Peptide Conjugate as a Potent Antibacterial Agent for <i>Pseudomonas aeruginosa</i> Infections.

ACS central science·2025
Same author

Toward a formulation of a CISS theory with the inclusion of two-particle relativistic effects, electron-phonon coupling, and electron-electron correlation. An application to NMR-based chiral discrimination.

The Journal of chemical physics·2025

Aligned electrospun nanofibers offer significant advantages for tissue engineering by mimicking native tissue architecture. This review explores their design, function, and application in regenerating various tissues, highlighting challenges for clinical translation.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Tissue engineering utilizes scaffolds mimicking the extracellular matrix (ECM) for tissue repair.
  • Aligned electrospun nanofibers are promising due to their ability to guide cell behavior and replicate native tissue anisotropy.

Purpose of the Study:

  • To review aligned nanofibers from a design-to-function perspective.
  • To analyze the influence of fiber alignment on bone, neuronal, cardiac, and muscle tissue regeneration.
  • To critically assess the clinical translation of electrospun nanofiber platforms.

Main Methods:

  • Discussion of electrospinning principles and material selection.
  • Analysis of strategies for controlling fiber alignment.
  • Review of preclinical studies integrating bioactive cues with aligned scaffolds.

More Related Videos

Postproduction Processing of Electrospun Fibres for Tissue Engineering
15:52

Postproduction Processing of Electrospun Fibres for Tissue Engineering

Published on: August 9, 2012

Electrospinning Fundamentals: Optimizing Solution and Apparatus Parameters
07:57

Electrospinning Fundamentals: Optimizing Solution and Apparatus Parameters

Published on: January 21, 2011

Related Experiment Videos

Last Updated: Jul 15, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Postproduction Processing of Electrospun Fibres for Tissue Engineering
15:52

Postproduction Processing of Electrospun Fibres for Tissue Engineering

Published on: August 9, 2012

Electrospinning Fundamentals: Optimizing Solution and Apparatus Parameters
07:57

Electrospinning Fundamentals: Optimizing Solution and Apparatus Parameters

Published on: January 21, 2011

Main Results:

  • Fiber alignment influences cell adhesion, migration, cytoskeletal organization, and differentiation.
  • Aligned nanofibers show potential in regenerating bone, neuronal, cardiac, and muscle tissues.
  • Bioactive cues enhance the performance of aligned nanofiber scaffolds.

Conclusions:

  • Aligned nanofibers present a viable strategy for tissue regeneration, but clinical translation faces hurdles.
  • Scale-up, reproducibility, pore architecture, and in vivo validation are key barriers.
  • Emerging directions include the development of 3D aligned scaffolds.