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Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles
Published on: May 26, 2023
Metal-Organic Frameworks (MOFs) for the Delivery of Small-Molecule Therapeutics
Pei-Hong Tong1, Xi-Le Hu1, Kai-Cheng Yan1
1Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, 130 Meilong Rd, Shanghai200237, China.
Abstract:
As cutting-edge porous materials, the properties of metal-organic frameworks (MOFs) are governed by their metal nodes and organic linkers, as well as the assembly mode of these subunits. This allows the loading capacity of MOFs for small-molecule drugs to be readily tailored by rationally adjusting their structures and physicochemical properties. Furthermore, the introduction of additional functional groups into MOFs can enable the stimuli-responsive release of small-molecule drugs, thus rendering MOFs promising candidates for small-molecule drug delivery. With this perspective, we summarize the advances in the construction of MOF-based small-molecule drug delivery carriers and analyze the advantages and limitations of the various loading strategies for small-molecule drugs. We also introduce drug release mechanisms and their application for the targeted treatment of various human diseases. In particular, this perspective describes how the corresponding drug-loading strategies should be selected based on the inherent physicochemical properties of the small-molecule drugs and the specific biomedical application, in order to facilitate clinical translation.
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