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Immune cell labelling and tracking: implications for adoptive cell transfer therapies
Filippo Galli1, Michela Varani2, Chiara Lauri2
1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy. filippo.galli@hotmail.com.
EJNMMI Radiopharmacy and Chemistry
|February 4, 2021
Summary
Non-invasive imaging techniques help track immune cells in adoptive cell transfer therapies. Labeling immune cells with probes can reveal biological mechanisms and predict therapeutic outcomes for cancer treatment.
Area of Science:
- Immunology
- Oncology
- Medical Imaging
Background:
- Understanding tumor-infiltrating immune cells is crucial for developing targeted immunotherapies.
- Adoptive cell transfer (ACT) therapies, like CAR-T cell therapy, show success in treating cancer.
- Research is expanding ACT approaches to new cancer types and cell targets.
Purpose of the Study:
- To review non-invasive imaging methods for monitoring immune therapeutic cells in cancer treatment.
- To evaluate the efficacy of these imaging techniques in preclinical and clinical settings.
Main Methods:
- Systematic literature search of PubMed and Scopus databases.
- Focus on studies imaging cell tracking in humans and preclinical models.
- Analysis of techniques for non-invasive monitoring of immune cell biodistribution, trafficking, and fate.
Main Results:
- Various labeling strategies using radiopharmaceuticals, contrast agents, or optical probes are available.
- These labeling methods can elucidate biological mechanisms and predict therapeutic outcomes.
- No single imaging technique is currently established as the gold standard for immune cell tracking in ACT.
Conclusions:
- Non-invasive imaging is essential for understanding immune cell behavior in ACT therapies.
- Technological advancements in labeling and imaging hold promise for personalized cancer treatment.
- Further research is needed to establish standardized imaging protocols for immune cell tracking.
