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Updated: Apr 30, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Radiopharmaceuticals for imaging T-cells.

Chiara Lauri¹, Erik Aarntzen², Andor W Glaudemans²

¹Nuclear Medicine Unit, Department of Medical-Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.

Seminars in Nuclear Medicine

|April 28, 2026

Summary

This summary is machine-generated.

In vivo T-lymphocyte tracking advances understanding of autoimmune and cancer diseases. This immune-imaging approach enables personalized therapies and precision medicine for improved patient outcomes.

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Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling

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Published on: October 27, 2023

Area of Science:

Immunology
Medical Imaging
Oncology

Background:

In vivo tracking of T-lymphocytes is crucial for understanding immune responses in autoimmune and cancer diseases.
This approach offers insights into immune system mechanisms, paving the way for personalized therapies.
T-lymphocytes possess accessible surface markers (CD3, CD4, CD8) suitable for immune-imaging.

Purpose of the Study:

To provide a comprehensive overview of T-cell imaging strategies.
To highlight current and future clinical applications in autoimmune diseases and immune-oncology.
To discuss advancements and challenges in translating T-cell imaging to clinical practice.

Main Methods:

Development of highly sensitive and specific radiopharmaceuticals for SPECT and PET imaging.
Non-invasive visualization and quantification of T-lymphocytes and their targets.
Assessment of T-cell functional status in tumor microenvironments and inflammatory sites.

Main Results:

T-cell imaging enables early disease detection and personalized treatment monitoring.
Immune-imaging provides insights into immune cell dynamics in disease pathogenesis.
Radiopharmaceuticals target key T-lymphocyte markers like CD3, CD4, and CD8.

Conclusions:

T-cell imaging is a pivotal tool for precision medicine in autoimmune disorders and oncology.
This technology has the potential to significantly improve patient outcomes.
Overcoming translation challenges is key to widespread clinical adoption of T-cell imaging.