Correlation between ¹⁸ F-FDG PET/CT semiquantitative parameters and Ki-67 expression in pulmonary mucosa-associated...

This study aims to investigate the correlation between ¹⁸ F-Fluoro-d-glucose positron emission tomography/computed tomography (¹⁸ F-FDG PET/CT) semiquantitative parameters and Ki-67 expression in pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma.

Twenty-eight patients with histologically confirmed pulmonary MALT lymphoma in 29 lesions who underwent ¹⁸ F-FDG PET/CT were retrospectively analysed. PET/CT images were analysed visually and semiquantitatively by measuring maximum standardized uptake value (SUV_max ), mean standardized uptake value (SUV_mean ), metabolic tumour volume (MTV) and total lesion glycolysis (TLG). The correlation between morphological pattern, tumour size, Ki-67 expression and PET/CT semiquantitative parameters were also analysed.

There were 16 male patients (57.1%) and 12 female patients (42.9%), and the mean age was 57.6 ± 9.7 years (range 43-73 years). Twenty-nine pulmonary lesions were identified in 28 patients: 12 (41.4%) presenting as consolidation, 9 (31.0%) as nodules, 5 (17.2%) as masses and 3 (10.3%) as ground glass opacities (GGOs). All of the 29 lesions were ¹⁸ F-FDG avid. SUV_max of the lesions was 4.4 ± 3.0 (range 1.1-15.3), SUV_mean was 2.8 ± 1.9 (range 0.8-10.3), MTV was 15.9 ± 17.6 (range 0.9-82.1) and TLG was 48.7 ± 56.6 (range 0.9-205.6). The PET/CT semiquantitative parameters were not correlated with morphological pattern of pulmonary MALT lymphoma, which were correlated significantly with tumour size and Ki-67 expression.

Pulmonary MALT lymphomas are ¹⁸ F-FDG avid, and ¹⁸ F-FDG PET/CT semiquantitative parameters (SUV_max , SUV_mean , MTV and TLG) are significantly correlated with tumour size and Ki-67 expression. ¹⁸ F-FDG PET/CT plays a potential role in identifying lung MALT lymphomas with higher proliferation and more aggressive behaviour in clinical practice.