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LncRNA FOXP4-AS1 Is Involved in Cervical Cancer Progression via Regulating miR-136-5p/CBX4 Axis.

Juan Zhao1, Ting Yang1, Long Li1

  • 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, People's Republic of China.

Oncotargets and Therapy
|April 8, 2020
PubMed
Summary
This summary is machine-generated.

Long non-coding RNA FOXP4-AS1 (forkhead box P4 antisense RNA 1) is highly expressed in cervical cancer (CC). This lncRNA promotes CC cell proliferation, migration, and invasion, suggesting it as a potential therapeutic biomarker.

Keywords:
CBX4FOXP4-AS1cervical cancermiR-136-5p

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Area of Science:

  • Molecular Oncology
  • Cancer Genomics
  • Epigenetics

Background:

  • Cervical cancer (CC) poses a significant global health challenge for women.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer development, including CC.

Purpose of the Study:

  • To investigate the expression levels of lncRNA FOXP4-AS1 (forkhead box P4 antisense RNA 1) in cervical cancer.
  • To elucidate the functional role of FOXP4-AS1 in CC cell behavior and its underlying molecular mechanism.

Main Methods:

  • Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) was used to measure FOXP4-AS1 expression in CC and normal cell lines.
  • Functional assays assessed the impact of FOXP4-AS1 on CC cell proliferation, migration, and invasion.
  • Bioinformatic tools and luciferase reporter assays were employed to identify downstream targets.

Main Results:

  • FOXP4-AS1 expression was significantly elevated in cervical cancer cell lines compared to normal cells.
  • Overexpression of FOXP4-AS1 enhanced CC cell proliferation, migration, and invasion.
  • Knockdown of FOXP4-AS1 inhibited these cellular processes.
  • FOXP4-AS1 functions as a competing endogenous RNA (ceRNA) for miR-136-5p, regulating Chromobox 4 (CBX4) expression.

Conclusions:

  • FOXP4-AS1 exhibits oncogenic properties in cervical cancer.
  • The FOXP4-AS1/miR-136-5p/CBX4 axis represents a potential therapeutic target for cervical cancer treatment.
  • FOXP4-AS1 may serve as a novel diagnostic and therapeutic biomarker for CC.