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Microbubbles are crucial for microfluidics, enabling precise manipulation through acoustic, thermodynamic, and chemical methods. This review explores their applications and future potential in micromanipulation.

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Area of Science:

  • Microfluidics
  • Biomedical Engineering
  • Acoustics
  • Thermodynamics
  • Chemical Engineering

Background:

  • Microfluidic devices and microscale actuation technologies are advancing rapidly.
  • Microbubbles exhibit unique properties responding to various energy sources and gas-liquid interactions.
  • Bubble-based micromanipulation offers non-invasive, selective, and precise microscale operations.

Purpose of the Study:

  • To review the morphological characteristics and formation of microbubbles.
  • To describe the theoretical foundations and mechanisms of microbubble-based micromanipulation.
  • To critically assess the applications and advances of microbubbles in microfluidics.

Main Methods:

  • Review of existing literature on microbubble formation and properties.
  • Analysis of micromanipulation strategies using acoustic, thermodynamic, and chemical stimuli.
  • Examination of diverse applications including microflow control and microrobotics.

Main Results:

  • Detailed description of microbubble characteristics and formation processes.
  • Explanation of micromanipulation mechanisms driven by different energy sources.
  • Compilation of current applications in microfluidics, from flow control to biomedical uses.

Conclusions:

  • Microbubbles are versatile tools for advanced micromanipulation in microfluidics.
  • Significant progress has been made in bubble-based strategies for precise microscale operations.
  • Future research should focus on designing novel microbubble-based micromanipulation tools.