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Related Experiment Video

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Frailty Assessment in an Aging Mouse Model
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Frailty syndrome: A target for functional nutrients?

Sergio Davinelli1, Graziamaria Corbi1, Giovanni Scapagnini1

  • 1Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.

Mechanisms of Ageing and Development
|February 4, 2021
PubMed
Summary

Frailty, a decline in physiological reserve in older adults, can be reversed. Emerging functional nutrients show promise in preventing and mitigating frailty through targeted interventions.

Keywords:
AgeingDietFrailtyNutrientsNutrition

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Physiology

Background:

  • Frailty is a complex late-life phenotype marked by decreased physiological reserve and increased vulnerability to stressors.
  • While its causes are not fully understood, aging processes and interconnected mechanisms are implicated.
  • Frailty is recognized as a dynamic condition, offering potential for prevention, delay, or reversal.

Purpose of the Study:

  • To discuss the role of emerging functional nutrients in modifying the frailty syndrome.
  • To highlight the potential of specific dietary components beyond basic nutrition to enhance function and reduce frailty.
  • To emphasize the need for further research into functional nutrients for clinical frailty management.

Main Methods:

  • Review of current literature on frailty, aging, and nutrition.
  • Discussion of proposed mechanisms linking functional nutrients to frailty.
  • Synthesis of evidence supporting a multidomain approach to frailty, including nutrition.

Main Results:

  • Nutrient deficiencies are consistently linked to frailty.
  • Specific dietary components may offer functional benefits beyond traditional nutritional value.
  • Functional nutrients present a promising, cost-effective strategy for frailty management.

Conclusions:

  • A multidomain approach, particularly proper nutrition, is crucial for preventing and reducing frailty in older adults.
  • Emerging functional nutrients warrant further investigation for their potential to alter the course of frailty.
  • Mechanistic studies and clinical trials are essential to define the role of functional nutrients in managing frailty.