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3D Whole-heart Myocardial Tissue Analysis

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Published on: April 12, 2017

Engineering and Assessing Cardiac Tissue Complexity.

Karine Tadevosyan^1,2, Olalla Iglesias-García^1,2,3,4, Manuel M Mazo^3,4,5

¹Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL) and Program for Clinical Translation of Regenerative Medicine in Catalonia (P-CMRC), 08908 L'Hospitalet del Llobregat, Spain.

International Journal of Molecular Sciences

|February 5, 2021

Summary

Researchers are advancing cardiac tissue engineering for heart repair and disease modeling. Current challenges include achieving mature, native-like tissue properties and standardizing assessment methods for better comparison and development.

Keywords:

cardiac tissue engineering cardiomyocytes human heart pluripotent stem cells tissue maturation

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Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Area of Science:

Regenerative Medicine
Cardiac Tissue Engineering
Cardiovascular Research

Background:

Cardiac tissue engineering is a key area in regenerative medicine, offering potential for cardiac disease modeling, cardiotoxicity testing, and cardiovascular repair.
Significant progress has been made in generating functional human engineered cardiac tissues over the past two decades.
Current engineered cardiac tissues lack the full maturity and properties of native adult heart tissue.

Purpose of the Study:

To provide an overview of current approaches for generating functional cardiac tissues.
To discuss various cell sources, biomaterials, and engineering strategies employed.
To review functional assays for evaluating cardiac maturation at cellular and tissue levels and propose a unified framework for comparison.

Main Methods:

Review of existing literature on cardiac tissue engineering methodologies.
Discussion of different cell sources (e.g., stem cells, primary cells).
Analysis of biomaterials and engineering strategies (e.g., scaffolds, bioreactors).
Evaluation of functional assays for assessing tissue maturation and functionality.

Main Results:

Identification of diverse cell sources, biomaterials, and engineering strategies used in cardiac tissue engineering.
Highlighting the heterogeneity in functional assessment methods, complicating direct comparison of engineered tissues.
Emphasis on the need for standardized evaluation frameworks to advance the field.

Conclusions:

Engineered cardiac tissues show promise but require further development to match native tissue properties.
Standardizing methodologies for generation and assessment is crucial for progress.
A unified framework will accelerate the development of tailored engineered cardiac tissues for specific applications.