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Related Concept Videos

Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
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Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
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When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
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Related Experiment Video

Updated: Nov 18, 2025

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
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5-HT/GABA interaction in neurodevelopment and plasticity.

Gabriele Deidda1, Massimo Pierucci1, Vincenzo Crunelli2

  • 1Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.

Progress in Brain Research
|February 5, 2021
PubMed
Summary

This chapter explores how serotonin (5-HT) interacts with GABA to influence brain development and plasticity throughout life. Understanding this relationship is key to comprehending neurodevelopmental processes.

Keywords:
5-HTAdult neurogenesisCritical periodGABANeurodevelopmentPlasticitySomatosensory cortexVisual cortex

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Neurochemistry

Background:

  • The adult brain develops through complex, multi-stage processes influenced by genetics, environment, and neural activity.
  • Neuronal circuits mature postnatally in an experience-dependent manner during critical plasticity periods, though plasticity persists in adulthood.
  • The neurotransmitter GABA is crucial across all neurodevelopmental stages.

Purpose of the Study:

  • To elucidate the interaction between serotonin (5-HT) and GABA.
  • To describe the regulatory roles of 5-HT and GABA in neurodevelopment.
  • To explain the involvement of 5-HT and GABA in brain plasticity.

Main Methods:

  • Literature review and synthesis of existing research on 5-HT and GABA.
  • Analysis of molecular and cellular mechanisms underlying neurodevelopment.
  • Examination of neurophysiological studies on brain plasticity.

Main Results:

  • GABAergic signaling is fundamental to neurodevelopment and plasticity.
  • Serotonin modulates GABAergic neurotransmission.
  • The interplay between 5-HT and GABA shapes neuronal circuit maturation and adult plasticity.

Conclusions:

  • The interaction between 5-HT and GABA is a critical determinant of neurodevelopmental trajectories.
  • Understanding this interaction provides insights into maintaining brain plasticity across the lifespan.
  • This chapter highlights the significance of GABAergic systems in neural development and adult brain function.