The microbiome and host mucosal interactions in urinary tract diseases
Bernadette Jones-Freeman1, Michelle Chonwerawong2,3, Vanessa R Marcelino2,3
1Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Mucosal Immunology
|February 5, 2021
Summary
The urinary tract
Area of Science:
- Urology
- Microbiology
- Immunology
Background:
- The urinary tract, including the bladder, ureters, and kidneys, is vital for waste filtration and homeostasis.
- Its function is interconnected with the genitourinary and gastrointestinal systems, each hosting distinct microbial communities (microbiota).
- The role of microbiota and their metabolites in urinary tract health and disease is not fully understood.
Purpose of the Study:
- To review the current literature on the impact of the microbiota on the urinary tract.
- To investigate the association between microbiota changes and urinary tract diseases.
- To explore future research directions and therapeutic potential.
Main Methods:
- Literature review of existing studies on the urinary tract microbiome.
- Analysis of the relationship between microbiota and urinary tract conditions.
- Discussion of emerging technologies and microbiome-based medicine.
Main Results:
- The microbiota influences the urinary tract in both healthy and diseased states.
- Dysbiosis may be implicated in conditions such as urinary stones, acute kidney injury, chronic kidney disease, and urinary tract infections.
- Emerging technologies offer new ways to study the urinary microbiome.
Conclusions:
- The urinary tract microbiota plays a significant role in maintaining homeostasis and influencing disease pathogenesis.
- Further research into the urinary microbiome is warranted.
- Microbiome-based interventions show promise for treating urinary tract conditions.
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