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Pre-Exposure Prophylaxis for COVID-19 in Pregnant Women
Melissa C Fesler1,2, Raphael B Stricker1,2
1Alan E. Beer Medical Center for Reproductive Immunology, Los Gatos, CA, USA.
International Journal of General Medicine
|February 5, 2021
Summary
Pregnant women face severe COVID-19 risks. Hydroxychloroquine pre-exposure prophylaxis (PrEP) offers a safe strategy to prevent complications and severe illness in this high-risk group.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Pharmacology
Background:
- Pregnant women are a vulnerable population with increased risk of severe COVID-19 outcomes, including preterm delivery, respiratory failure, and mortality.
- Current COVID-19 vaccine development excludes pregnant women, potentially limiting their access to preventative measures due to insufficient safety data in pregnancy.
Purpose of the Study:
- To explore the potential of pre-exposure prophylaxis (PrEP) as an alternative strategy for preventing COVID-19 in pregnant women.
- To evaluate the safety and feasibility of using hydroxychloroquine for PrEP in pregnant individuals.
Main Methods:
- Review of existing literature on COVID-19 in pregnancy.
- Analysis of the pharmacological profile and safety data of hydroxychloroquine in pregnant populations.
- Discussion of hydroxychloroquine as a potential PrEP agent.
Main Results:
- Hydroxychloroquine is an approved medication with established safety profiles for certain gestational conditions.
- The use of hydroxychloroquine as PrEP presents a viable option for mitigating COVID-19 risks in pregnant women.
Conclusions:
- Pre-exposure prophylaxis with hydroxychloroquine is proposed as a safe and accessible method to prevent COVID-19 complications in pregnant women.
- Further research and clinical trials are warranted to confirm the efficacy and safety of hydroxychloroquine PrEP during pregnancy.
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