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Circulating bioactive sclerostin levels in an Austrian population-based cohort
Katharina Kerschan-Schindl1, Ursula Föger-Samwald2, Andreas Gleiss3
1Department of Physical Medicine, Rehabilitation and Occupational Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. katharina.kerschan-schindl@meduniwien.ac.at.
Wiener Klinische Wochenschrift
|February 5, 2021
Summary
Serum bioactive sclerostin levels, a key bone metabolism regulator, are higher in men and increase with age. This finding supports sclerostin as a robust biomarker for bone health.
Area of Science:
- Biochemistry
- Bone Biology
- Endocrinology
Background:
- Circulating sclerostin reflects bone sclerostin levels, a negative regulator of bone mass.
- Previous studies show variations in total serum sclerostin by sex and age.
- A new ELISA assay measures bioactive sclerostin, offering a more specific assessment.
Purpose of the Study:
- To investigate serum levels of bioactive sclerostin in an Austrian population.
- To explore correlations between bioactive sclerostin and demographic/physiological factors.
Main Methods:
- Cross-sectional observational study of 235 healthy Austrian subjects.
- Bioactive sclerostin levels measured using a specific ELISA assay (Biomedica).
Main Results:
- Bioactive sclerostin levels were 24% higher in men than in women.
- Levels positively correlated with age (r=0.47).
- Positive correlations observed with body mass index and bone mineral density.
Conclusions:
- Results align with existing literature using different sclerostin assays.
- Bioactive sclerostin determination in blood is a reliable indicator of bone metabolism.
- This assay provides a robust parameter for assessing bone health.
