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3D printed spherical mini-tablets: Geometry versus composition effects in controlling dissolution from personalised

Sejad Ayyoubi1, Jose R Cerda2, Raquel Fernández-García2

  • 1Department of Pharmaceutics and Food Science, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain; School of Pharmacy, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, the Netherlands.

International Journal of Pharmaceutics
|February 5, 2021
PubMed
Summary
This summary is machine-generated.

3D printing enables personalized medicine by creating custom nifedipine mini-tablets for hypertension. This advanced technology offers high drug loading and controlled release, adapting medication to individual patient needs.

Keywords:
3D printingFused Deposition Modelling (FDM)Mini-tabletsNifedipinehot-melt extrusion (HME)

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Personalized Medicine

Background:

  • Oral dosage forms are widely used but lack personalization, leading to adverse effects.
  • 3D printing offers a promising avenue for developing patient-specific medications.

Purpose of the Study:

  • To develop 3D printed personalized solid dosage forms for hypertensive patients using nifedipine.
  • To investigate the impact of formulation and geometry on drug loading and release.

Main Methods:

  • 3D printing of spherical mini-tablets using polyvinyl alcohol (PVA), Kollidon VA64 (KVA), and ethylcellulose (EC) filaments.
  • Drug loading via passive diffusion (PD) and hot-melt extrusion (HME).
  • Characterization of drug dissolution, surface area, and physicochemical properties (PXRD).

Main Results:

  • Hot-melt extrusion (HME) achieved a 13-fold higher drug loading compared to passive diffusion (PD).
  • Composition significantly influenced drug dissolution more than geometry or surface area.
  • Kollidon VA64 (KVA)-based formulations showed amorphous nifedipine and controlled release over 24 hours.

Conclusions:

  • 3D printed mini-tablets offer a versatile platform for personalized solid dosage forms.
  • The technology allows for high drug loading and tailored drug release profiles.
  • Formulation composition is key to achieving desired dissolution control in personalized medicines.