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Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation

Zeyu Ma1, Gang Xu2, Yingying Shen1

  • 1Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006, Hangzhou, China; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.

Pharmacological Research
|February 5, 2021
PubMed

Schisandrin B (Sch B) is the major active constituent of the traditional Chinese medicine Schisandra chinensis and has anti-inflammatory activity, but the target of Sch B remains unclear. T helper 17 (TH17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases. Here, we showed that Sch B could decrease IL-17A production of CD4+ T cells by targeting STAT3 in vitro. Importantly, Sch B has therapeutic effects on DSS-induced acute and chronic colitis, CD4+CD45RBhigh T cell-induced colitis. Furthermore, we identified TH17 cells as the direct target of Sch B for mediating its anti-inflammatory activity. Sch B could serve as a lead for developing new therapeutics against TH17 cells or IL-17A cytokine-driven diseases.

Keywords:
Chemical compounds studies in this article Schisandrin B (PubChem CID: 108130)Inflammatory bowel diseaseSTAT3T(H)17 cell

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