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Cardiorespiratory Functioning in Youth with Persistent Post-Concussion Symptoms: A Pilot Study.

Aliyah Snyder1,2, Christopher Sheridan2,3, Alexandra Tanner4

  • 1Department of Psychiatry, University of California, Los Angeles, CA 90095, USA.

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|February 6, 2021
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Summary
This summary is machine-generated.

Youth with persistent post-concussive symptoms (PPCS) show altered breathing patterns, specifically lower end-tidal CO2 (EtCO2). These cardiorespiratory changes may link to neurobehavioral issues impacting concussion recovery.

Keywords:
autonomic functioningbrain injurycardiorespiratoryconcussionend-tidal CO2mild traumatic brain injurypost-concussion symptoms

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Area of Science:

  • Neuroscience
  • Cardiorespiratory Physiology
  • Pediatric Health

Background:

  • Autonomic nervous system (ANS) dysregulation is implicated in persistent post-concussive symptoms (PPCS).
  • Breathing dysfunction, influenced by the ANS, is understudied in youth following concussion.
  • Understanding cardiorespiratory changes is crucial for youth concussion recovery.

Purpose of the Study:

  • Evaluate baseline cardiorespiratory functioning in youth with PPCS.
  • Examine the relationship between cardiorespiratory variables and neurobehavioral outcomes in youth PPCS.
  • Investigate potential links between breathing patterns and concussion recovery.

Main Methods:

  • Recruited participants aged 13-25: 13 with PPCS and 12 non-injured controls.
  • Utilized capnometry to measure end-tidal CO2 (EtCO2), SaO2, respiration rate (RR), and pulse rate (PR) at rest.
  • Correlated cardiorespiratory data with neurobehavioral assessments (depression, symptom severity, cognitive catastrophizing, processing speed).

Main Results:

  • PPCS youth exhibited significantly lower mean EtCO2 compared to controls (36.3 vs. control mean).
  • An altered inter-correlation between EtCO2 and RR was observed in the PPCS group.
  • Cardiorespiratory variables correlated with neurobehavioral outcomes when groups were combined.

Conclusions:

  • Breathing dynamics appear altered in youth experiencing PPCS.
  • Cardiorespiratory outcomes may be associated with neurobehavioral factors influencing concussion recovery.
  • Further research into ANS and breathing dysfunction in youth concussion is warranted.