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Updated: Nov 18, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Recent Advances in p53

Gabriella D'Orazi1,2

  • 1Department of Research, Unit of Cellular Networks, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.

Biomolecules
|February 6, 2021
PubMed

Insights

The tumor suppressor protein p53 (TP53) is a crucial transcription factor. It regulates genes for DNA repair, cell death, and cell cycle arrest in response to cellular stress.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Genetics

Background:

  • The tumor suppressor protein p53 (TP53) functions as a critical transcription factor.
  • TP53 responds to diverse cellular stress signals.

Discussion:

  • TP53 regulates genes involved in DNA repair.
  • TP53 controls apoptosis and cell cycle arrest.
  • TP53 influences senescence and cellular metabolism.

Key Insights:

  • TP53 is a central regulator of cellular stress responses.
  • Its multifaceted roles are essential for maintaining genomic stability.
  • Dysregulation of TP53 is implicated in various diseases, including cancer.

Outlook:

  • Further research into TP53 pathways can reveal novel therapeutic targets.
  • Understanding TP53's complex regulatory network is key for disease intervention.
  • Investigating TP53's role in metabolism may offer new insights into metabolic disorders.

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