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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Updated: Nov 18, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
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Predictive immunogenetic markers in COVID-19.

Mauro de Meira Leite1, Faviel F Gonzalez-Galarza2, Bruno Conde Costa da Silva1

  • 1Genetics of Complex Diseases Laboratory, Federal University of Pará, Belém, Brazil; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Belém, Brazil.

Human Immunology
|February 6, 2021
PubMed
Summary
This summary is machine-generated.

Host genetics, including HLA-B alleles and cytokine gene polymorphisms, may influence COVID-19 outcomes. This study correlated gene frequencies with country-level death rates, revealing potential genetic markers for disease severity.

Keywords:
COVID-19Cytokine polymorphismsHLA-BKIR

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Area of Science:

  • Immunogenetics
  • Infectious disease epidemiology

Background:

  • Host genetics are crucial for understanding COVID-19 progression and prognosis.
  • Limited host genetic data was available early in the pandemic.

Purpose of the Study:

  • To investigate the correlation between frequencies of specific immunogenetic factors and COVID-19 Case Fatality Rate (CFR) and Daily Death Rates (DDR).
  • To explore the potential role of HLA-B alleles and cytokine gene polymorphisms (IL6, IL10, IL12B) in COVID-19 mortality.

Main Methods:

  • Retrieved HLA-B allele, KIR gene, and cytokine gene single nucleotide polymorphism (SNP) frequency data from public databases (Allele Frequency Net Database, Ensembl).
  • Correlated genetic frequency data with country-specific CFR and DDR for COVID-19.

Main Results:

  • Observed significant correlations between eight HLA-B alleles and polymorphisms in IL6, IL10, and IL12B genes with DDR.
  • HLA-B allele associations suggest a link between peptide-binding affinity to SARS-CoV-2 and DDR.
  • Cytokine gene polymorphisms were also associated with daily death rates.

Conclusions:

  • Specific host genetic factors, particularly HLA-B alleles and cytokine gene polymorphisms, show associations with COVID-19 mortality rates.
  • Findings support the investigation of host genetic markers for predicting COVID-19 severity and outcomes.
  • Allele-specific differences in SARS-CoV-2 peptide binding may contribute to observed mortality variations.