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Translational PET applications for brain circuit mapping with transgenic neuromodulation tools
Matthew A Boehm1, Jordi Bonaventura2, Juan L Gomez2
1National Institute on Drug Abuse Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, United States; Department of Neuroscience, Brown University, Providence, RI 02906, United States.
Pharmacology, Biochemistry, and Behavior
|February 7, 2021
Summary
Transgenic neuromodulation tools like chemogenetics and optogenetics offer precise brain circuit control. Combining these with PET imaging enables in vivo tracking for future human therapies.
Area of Science:
- Neuroscience
- Molecular Biology
- Medical Imaging
Background:
- Transgenic neuromodulation tools (chemogenetics, optogenetics) enable precise neuronal manipulation.
- These tools map neuroanatomy, linking cellular activity to brain function and behavior.
- Preclinical success drives interest in translational applications for human therapies.
Purpose of the Study:
- To review the integration of transgenic tools with Positron Emission Tomography (PET) for in vivo brain circuit mapping.
- To explore the potential of PET for monitoring chemogenetic receptors and opsins in translational neuroscience.
- To propose future research directions for clinical applications.
Main Methods:
- Review of current literature combining transgenic neuromodulation techniques with PET imaging.
- Analysis of strategies for in vivo tracking of engineered receptors and opsins.
- Discussion of challenges and opportunities for translational research.
Main Results:
- PET imaging offers a promising solution for tracking transgenic tools in vivo.
- Successful integration of transgenic tools and PET facilitates brain circuit mapping and functional analysis.
- Current research highlights the potential for monitoring neuromodulation targets in preclinical models.
Conclusions:
- Combining transgenic tools with PET imaging is crucial for advancing translational neuroscience.
- Developing effective in vivo monitoring strategies is essential for the safe clinical application of neuromodulation.
- Future research should focus on refining PET-based tracking for human therapeutic development.
