[Immunity, aging and works of V.M.Dilman.]
A V Polevshchikov1, P G Nazarov1
1Institute of Experimental Medicine, 12 Acad. Pavlov str., St. Petersburg, 197376, Russian Federation,
Abstract:
The review, dedicated to the anniversary of the brilliant gerontologist, endocrinologist and oncologist Vladimir M. Dilman, provides a historical analysis of the hypotheses of immunocooperative interactions, which have been given a prominent place in his original concept of aging. The history of various T-cell populations and sub-populations is reviewed, and their functions are briefly analyzed in relation to age-specific changes in immunity. Also considered is the theory of inflammaging in the light of the concept of V.M.Dilman.
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