[Non-traditional view on traditional risk factors of cardiovascular diseases in seniors.]

Area of Science:

• Gerontology
• Cardiology
• Biochemistry

Background:

• Cardiovascular diseases (CVD) pose significant risks to the elderly population.
• Traditional risk factors for CVD may exhibit altered significance in aging individuals.
• Metabolic changes associated with aging require specific consideration in cardiovascular risk assessment.

Purpose of the Study:

• To investigate traditional CVD risk factors in elderly social groups, including the old and centenarians.
• To evaluate biochemical markers and specific conditions like atherosclerotic lesions and fatty liver degeneration in seniors.
• To explore the 'preventive paradox' in elderly men with coronary heart disease (CHD).

Main Methods:

• Analysis of biochemical markers in seniors, including lipids, fibrinogen, and uric acid.
• Examination of atherosclerotic lesions in coronary arteries of the elderly.
• Assessment of lipid spectrum characteristics, psychological features, and behavioral types in senior cardiovascular patients.

Main Results:

• Specific biochemical markers and metabolic signs of aging relevant to CVD were evaluated.
• Particularities of atherosclerotic lesions and links between coronary heart disease (CHD) and fatty liver were identified.
• In men over 60 with CHD, a 'preventive paradox' was observed where traditional risk factors' influence decreased, with low high-density lipoprotein cholesterol, reduced APO-A1, increased APO-B/APO-A1 ratio, and low physical activity becoming significant prognostic factors.

Conclusions:

• Traditional CVD risk factors require re-evaluation in the context of aging populations.
• Lipid profiles, particularly high-density lipoprotein cholesterol and apolipoprotein ratios, are critical prognostic indicators in elderly men with CHD.
• Low physical activity is a significant factor influencing cardiovascular outcomes in older adults.