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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Cutaneous melanin and glaucoma: a case control study.

Nanda K Gurung1, Amer F Alsoudi2,3, Prachand Gautam1

  • 1Department of Glaucoma, Lumbini Eye Institute, Bhairahawa, Nepal.

Current Eye Research
|February 8, 2021
PubMed
Summary
This summary is machine-generated.

This study objectively measured skin melanin and found no significant link between pigmentation and glaucoma risk. Glaucoma research should explore other factors beyond skin color.

Keywords:
GlaucomaNepalmelaninocular hypertensionopen angleskin pigmentation

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Area of Science:

  • Ophthalmology
  • Genetics
  • Dermatology

Background:

  • Previous research suggested darker skin color increases glaucoma risk, but relied on subjective assessments.
  • Objective measurement of skin melanin is needed to validate this association.

Purpose of the Study:

  • To objectively determine if skin melanin levels are a risk factor for glaucoma.
  • To investigate the relationship between skin pigmentation and glaucoma using quantitative measurements.

Main Methods:

  • A case-control study was conducted in Nepal with 100 glaucoma cases and 100 age-matched controls.
  • Skin melanin was measured objectively using a colorimeter on the inner arm and forehead.
  • Statistical analysis adjusted for sex and country of residence.

Main Results:

  • High reliability was observed in melanin measurements (intra-class correlation > 0.97).
  • No significant difference in mean skin melanin values was found between glaucoma cases and controls.
  • Adjusted analyses showed no association between skin melanin and glaucoma presence (ORs near 1.0).

Conclusions:

  • This study did not find a significant association between skin pigmentation and glaucoma.
  • Objective measurements indicate skin melanin is not a risk factor for glaucoma in this population.