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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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SARS-CoV-2 tropism: what urologists need to know
1Urology Department, Wexham Park NHS Hospital, 15 Yew Tree Road, Slough, Berkshire, SL1 2AA UK.
Summary
Viral infections in urology, including COVID-19, can directly impact the genitourinary tract. Urologists must leverage existing knowledge of viral urinary tract infections to manage SARS-CoV-2.
Area of Science:
- Urology
- Infectious Diseases
- Virology
Background:
- Viral infections are uncommon in urology, often underreported.
- COVID-19's impact extends beyond indirect practice disruptions.
- Emerging evidence suggests direct urological involvement in SARS-CoV-2 infections.
Purpose of the Study:
- To review available data on genitourinary tract involvement by SARS-CoV-2.
- To explore similarities between COVID-19 and other known viral genitourinary infections.
- To understand the pathophysiologic impact of viral infections on the urogenital system.
Main Methods:
- Comprehensive literature review.
- Analysis of organotropism of SARS-CoV-2.
- Comparison with existing knowledge of viral infections in the genitourinary tract.
Main Results:
- The genitourinary tract can be a direct target of SARS-CoV-2.
- Understanding pathophysiologic similarities is crucial for managing viral urological conditions.
- COVID-19 presents unique challenges and potential long-term consequences for urological practice.
Conclusions:
- Urologists must adapt their expertise in managing viral urinary tract infections to address COVID-19.
- Preparedness for short- and long-term consequences of COVID-19 in urology is essential.
- Extrapolation of experience with viral infections is key for effective patient management.
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