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Related Experiment Video

Updated: Nov 18, 2025

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Interaction Between Mesenchymal Stem Cells and Retinal Degenerative Microenvironment.

Yu Lin^1,2, Xiang Ren^1,2, Yongjiang Chen³

¹The Research Laboratory of Ophthalmology and Vision Sciences, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Neuroscience

|February 8, 2021

Summary

This summary is machine-generated.

Mesenchymal stromal/stem cells (MSCs) show promise for treating retinal degenerative diseases (RDDs). This review explores MSCs

Keywords:

immunomodulation inflammation interaction licensing mesenchymal stem cells retinal degenerative diseases trophic tunneling nanotubes

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Last Updated: Nov 18, 2025

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Published on: February 12, 2018

Area of Science:

Ophthalmology and Regenerative Medicine

Background:

Retinal degenerative diseases (RDDs) cause irreversible vision loss with limited treatment options.
Stem cell therapy, particularly using mesenchymal stromal/stem cells (MSCs), is a promising approach for RDDs.
MSCs offer neurotrophic and immunomodulatory benefits with a favorable safety profile.

Purpose of the Study:

To review the interaction between MSCs and the retinal degenerative disease microenvironment.
To discuss balancing the therapeutic potential and safety of MSC ocular applications.

Main Methods:

Literature review of pre-clinical studies and clinical trials on MSCs for RDDs.
Analysis of MSC-retinal microenvironment interactions.
Evaluation of safety and efficacy data from clinical applications.

Main Results:

Pre-clinical studies indicate MSCs can delay retinal degeneration.
Clinical trials show promising safety but some therapies have not met efficacy endpoints.
Concerns exist regarding severe side effects in some unregulated "stem cell" clinics.

Conclusions:

MSCs hold significant therapeutic potential for RDDs, but challenges remain.
Further research is needed to optimize MSC-based therapies for retinal diseases.
Balancing efficacy and safety is crucial for successful clinical translation.