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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
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Updated: Nov 18, 2025

A Porcine Model of Acute Autologous Pulmonary Embolism
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Pulmonary angiosarcoma presenting with diffuse alveolar hemorrhage: a case report.

Min Yu1, Weibin Huang1, Yan Wang2

  • 1Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital & the First Affiliated Hospital of Southern University of Science and Technology & the Second Clinical School of Jinan University & Shenzhen Municipal Institute of Respiratory Medicine, Shenzhen, China.

Annals of Translational Medicine
|February 8, 2021
PubMed
Summary

Pulmonary angiosarcoma (PPA) can mimic diffuse alveolar hemorrhage (DAH). Definitive diagnosis often requires a lung biopsy, especially when initial tests are inconclusive.

Keywords:
Diffuse alveolar hemorrhage (DAH)case reportpulmonary angiosarcoma (PPA)pulmonary biopsy

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Area of Science:

  • Pulmonology
  • Oncology
  • Pathology

Background:

  • Pulmonary angiosarcoma (PPA) is a rare primary lung malignancy.
  • Diagnosis can be challenging due to nonspecific symptoms and imaging findings.

Observation:

  • A female patient presented with cough, hemoptysis, and dyspnea, initially suspected as diffuse alveolar hemorrhage (DAH).
  • Initial investigations including CT scans, laboratory tests (rheumatic, tumor markers), and cultures were inconclusive.
  • Despite empirical treatment for DAH, symptoms persisted, and pleural effusion analysis was negative.

Findings:

  • Thoracoscopic lung biopsy confirmed pulmonary angiosarcoma (PPA) via pathology and immunohistochemistry (IHC).
  • The case highlights the diagnostic difficulties in PPA presenting with DAH-like features.

Implications:

  • Consider PPA in patients with DAH and negative routine diagnostic workups.
  • Lung biopsy is crucial for definitive diagnosis of PPA when other methods fail.
  • Early consideration of PPA may improve diagnostic timelines and patient outcomes.