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Related Experiment Videos

A statistical procedure for measuring and evaluating performance in interlaboratory comparison programs.

D W Tholen1

  • 1College of American Pathologists Computer Center, Traverse City, Mich.

Archives of Pathology & Laboratory Medicine
|April 1, 1988
PubMed
Summary

A new statistical method precisely measures individual laboratory performance on proficiency tests, offering a more informative alternative to simple pass/fail rates. This approach enhances accuracy in evaluating laboratory quality and reduces the risk of false penalties.

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Area of Science:

  • * Laboratory medicine
  • * Clinical chemistry
  • * Biostatistics

Background:

  • * Laboratories require robust methods to assess performance on proficiency testing.
  • * Existing methods may lack the precision to accurately reflect laboratory performance.
  • * Regulatory and scientific needs demand sensitive and specific performance metrics.

Purpose of the Study:

  • * To introduce a novel statistic for measuring individual laboratory performance in quantitative interlaboratory proficiency tests.
  • * To establish a precise, quantitative method for evaluating laboratory performance that minimizes false penalties.
  • * To assess the validity and utility of the proposed statistic using real-world data.

Main Methods:

  • * Development of a performance statistic based on actual error relative to tolerable error.

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  • * Accumulation of the statistic across multiple challenges and analytes to estimate performance levels.
  • * Description and validation of the statistic's distribution.
  • * Presentation of a procedure for evaluating laboratories against performance goals.

    • Main Results:

    • * The proposed statistic provides a more informative measure of error than percentage of acceptable results.
    • * The statistic demonstrates greater power in detecting poor laboratory performance.
    • * Validation of the statistic's distribution and evaluation procedure using College of American Pathologists Chemistry Survey data.

    Conclusions:

    • * The developed statistic offers a precise and sensitive method for assessing individual laboratory performance in proficiency testing.
    • * This approach enhances the ability to identify laboratories needing improvement while minimizing the risk of unwarranted regulatory action.
    • * The method is validated and applicable for routine use in laboratory quality assessment.