Related Experiment Video
Updated: Nov 18, 2025
Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
Published on: January 26, 2024
Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden,
Kristian Alfsnes1, Nina Lagerqvist2, Sirkka Vene2
1Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Abstract:
Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-sequencing of samples collected between 7 and 36 days from onset of symptoms we identified dengue virus 3 (DENV-3) and a human pegivirus (HPgV). We conclude that the patient likely suffered from haemorrhagic symptoms due to an atypical severe and undiagnosed dengue infection.
