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Optimising factors affecting solid phase extraction performances of molecular imprinted polymer as recent sample
Gabriella Josephine Maranata1, Natasha Octavianti Surya1, Aliya Nur Hasanah1,2
1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, 5, Jatinangor, 45363, Sumedang, Indonesia.
Molecular imprinted solid-phase extraction (MISPE) enhances analyte extraction efficiency. Optimizing parameters like contact time, pH, and solvent choice is crucial for maximizing recovery and ensuring effective molecular recognition in analytical chemistry.
Area of Science:
- Analytical Chemistry
- Materials Science
Background:
- Molecular imprinted solid-phase extraction (MISPE) utilizes molecularly imprinted polymers as selective sorbents.
- MISPE offers improved extraction and purification compared to conventional solid-phase extraction (SPE).
Purpose of the Study:
- To address the complexity of variables in MISPE analysis.
- To highlight the necessity of optimizing MISPE extraction conditions for efficient analyte recovery.
Main Methods:
- Review and discussion of critical parameters influencing MISPE performance.
- Analysis of factors affecting sorption equilibrium, extraction time, and analyte-sorbent interactions.
Main Results:
- Optimization of parameters such as contact time, ion strength, pH, sorbent amount, flow rate, salt/buffer addition, and solvent selection is vital.
- Appropriate selection and quantity of factors significantly impact analyte-sorbent interactions and percentage recovery.
Conclusions:
- Future MISPE optimization requires careful consideration and adjustment of multiple factors.
- Fine-tuning these parameters is essential for establishing optimal interactions between sorbent and target molecules, leading to improved analytical results.
