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Photodynamic Therapy as a New Treatment for Chronic Rhinosinusitis - A Systematic Review
Anika Kaura1, Rishi Shukla2, Abigail Lamyman2
1Ear Institute, University College London, London, UK.
Turkish Archives of Otorhinolaryngology
|February 8, 2021
Summary
Photodynamic therapy (PDT) shows promise for chronic rhinosinusitis (CRS) by killing resistant bacteria in lab studies. However, more clinical research is needed to confirm its safety and effectiveness for patients.
Area of Science:
- Otolaryngology
- Photomedicine
Background:
- Chronic rhinosinusitis (CRS) presents a significant clinical challenge.
- Current treatments for CRS have limitations, driving the search for novel therapeutic approaches.
Purpose of the Study:
- To review the current evidence on the use of photodynamic therapy (PDT) for treating chronic rhinosinusitis.
- To assess the potential of PDT as a therapeutic option for CRS.
Main Methods:
- A comprehensive literature search was performed in MedLine, EMBASE, and TRIP Database from January 2000 to May 2020.
- Keywords included "photodynamic" or "phototherapy" or "photo" and "sinusitis" or "rhinosinusitis."
- Included studies encompassed in-vitro, animal, and human research.
Main Results:
- In-vitro studies demonstrate PDT's bactericidal efficacy against drug-resistant bacteria and biofilms.
- Limited clinical studies are available, indicating a need for further investigation.
- Evidence suggests PDT's potential, but clinical data remains scarce.
Conclusions:
- Photodynamic therapy exhibits promising in-vitro results for targeting pathogens involved in CRS.
- Larger, well-designed clinical trials are essential to evaluate PDT's safety, efficacy, delivery methods, and optimal patient selection for CRS treatment.
