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Pregnancy-associated decrease in lipid peroxidation in rat liver.
1Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Biochemistry International
|January 1, 1988
Summary
During rat pregnancy, hepatic lipid peroxidation significantly decreased, returning to normal levels postpartum. This reduction is linked to changes in phospholipids, lipid unsaturation, and increased antioxidant levels.
Area of Science:
- Biochemistry
- Physiology
Background:
- Lipid peroxidation is a marker of oxidative stress.
- Pregnancy involves significant physiological changes that can impact oxidative balance.
Purpose of the Study:
- To investigate changes in hepatic lipid peroxidation during rat gestation.
- To identify factors contributing to altered lipid peroxidation during pregnancy.
Main Methods:
- Measuring hepatic malonaldehyde content and lipid peroxidation.
- Assessing effects of inducers like ascorbate, NADPH, and cumene hydroperoxide.
- Analyzing hepatic mitochondria and microsomes.
Main Results:
- A significant decrease in hepatic malonaldehyde and lipid peroxidation was observed during gestation.
- Lipid peroxidation levels normalized approximately 3 days postpartum.
- Specific effects on mitochondrial and microsomal lipid peroxidation varied with inducers.
Conclusions:
- Pregnancy-induced reduction in hepatic lipid peroxidation is associated with decreased phospholipid content and lipid unsaturation.
- Increased antioxidant levels during gestation likely contribute to reduced oxidative stress.