Intramolecular Oxidative Coupling between Unactivated Aliphatic C-H and Aryl C-H Bonds
Yang Liao1, Yi Zhou2, Zhen Zhang2
1Department of Chemistry, Fudan University, Shanghai 200438, China.
Abstract:
Direct oxidative coupling of different inert C-H bonds is the most straightforward and environmentally benign method to construct C-C bonds. In this paper, we developed a Pd-catalyzed intramolecular oxidative coupling between unactivated aliphatic and aryl C-H bonds. This chemistry showed great potential to build up fused cyclic scaffolds from linear substrates through oxidative couplings. Privileged chromane and tetralin scaffolds were constructed from readily available linear starting materials in the absence of any organohalides and organometallic partners.
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