Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Air-permeable hydrogels through viscoelastic phase separation of aerogels.

Nature·2026
Same author

3D-Printed Milli-Fluidic Mixing-Extrusion Platform for Continuous, High-Throughput LNP Production.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Antibiotics stimulate protein transfer to persister cells.

Science (New York, N.Y.)·2026
Same author

Direct imaging-based gradient metasurface sensor enabling spectrometer-free ultrasensitive biomolecule detection.

Nature communications·2026
Same author

Reprogramming of TLR-Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer.

Cancer research·2026
Same author

Ion-triggered reconfigurable hydrogels with salt-enhanced mechanical and swelling properties via network topological adaptation.

Nature communications·2026

Related Experiment Video

Updated: Nov 18, 2025

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.1K

Ordered Mesoporous Microcapsules from Double Emulsion Confined Block Copolymer Self-Assembly.

Jörg G Werner1,2, Hyomin Lee1,3, Ulrich Wiesner4

  • 1John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.

ACS Nano
|February 8, 2021
PubMed
Summary

Researchers created novel mesoporous microcapsules using block copolymers and double emulsion templates. These robust, tunable capsules offer advanced filtration for macromolecular separation and purification.

Keywords:
gyroidmacromolecular permeabilitymicrofluidicsnanoporosityperiodic nanostructure

More Related Videos

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device
08:58

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Published on: December 25, 2015

16.4K
Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
07:39

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Published on: June 8, 2016

9.8K

Related Experiment Videos

Last Updated: Nov 18, 2025

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.1K
Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device
08:58

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Published on: December 25, 2015

16.4K
Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
07:39

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Published on: June 8, 2016

9.8K

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Developing advanced materials for separation and purification is crucial.
  • Mesoporous materials offer unique properties for controlled transport.
  • Polymeric microcapsules are versatile platforms for encapsulation and delivery.

Purpose of the Study:

  • To report the fabrication of mesoporous polymeric microcapsules with homogeneous, nanometer-scale pores.
  • To demonstrate the formation of microcapsules with tunable shell thickness and controlled morphology.
  • To develop robust microcapsules suitable for harsh conditions and explore their filtration capabilities.

Main Methods:

  • Confined self-assembly of amphiphilic block copolymers within water-in-oil-in-water double emulsion drops.
  • Utilizing a selective porogen to create mesopores in the microcapsule shell.
  • Employing a cross-linking method to enhance shell stability under harsh conditions.
  • Developing a dual-phase separation method for hierarchically porous shells.

Main Results:

  • Homogeneous polymeric microcapsules with tunable shell thickness (100s of nm to 10s of µm) were successfully fabricated.
  • Microcapsules with ordered gyroidal morphology and 3D-connected mesopores were achieved using a triblock terpolymer system.
  • Cross-linking enhanced shell stability against organic solvents.
  • pH-responsive permeability to polymeric solutes was observed, indicating potential for tunable macromolecular separation.
  • Hierarchically porous shells were fabricated, allowing further control over permeability.

Conclusions:

  • Mesoporous microcapsules with controlled pore structures and enhanced stability can be fabricated using block copolymer self-assembly in double emulsions.
  • The developed microcapsules demonstrate significant potential as tunable filtration media for macromolecular separation and purification.
  • Hierarchical porosity offers an additional avenue for precise control over microcapsule shell permeability.