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Updated: Nov 18, 2025

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Zebrafish as a potential biomaterial testing platform for bone tissue engineering application: A special note on

Selvaraj Vimalraj1, Rajamanikkam Yuvashree2, Gopal Hariprabu2

  • 1Centre for Biotechnology, Anna University, Chennai 600 025, Tamil Nadu, India; Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600 077, Tamil Nadu, India.

International Journal of Biological Macromolecules
|February 8, 2021
PubMed
Summary

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Zebrafish offer a cost-effective and efficient alternative to rodent models for testing biomaterials in vivo. This model accelerates the characterization of new biomaterials for bone tissue engineering applications.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Biomaterials are crucial for tissue engineering, impacting cell growth and regeneration.
  • Understanding host-biomaterial interactions is vital for successful implantation.
  • Current in vivo rodent models for biomaterial testing are tedious and technically challenging.

Purpose of the Study:

  • To review the zebrafish as a potential in vivo model for rapid biomaterial characterization.
  • To highlight the advantages of zebrafish over rodent models for biomaterial research.
  • To discuss the application of zebrafish in evaluating biomaterials for bone tissue engineering.

Main Methods:

  • Review of existing literature on zebrafish as a model organism in biomaterial research.
Keywords:
BiomaterialsBoneTissue engineeringZebrafish

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  • Comparison of zebrafish and rodent models for in vivo biomaterial testing.
  • Focus on chitosan-based bioactive materials and their evaluation in zebrafish.

    • Main Results:

    • Zebrafish exhibit bone morphogenesis signals similar to mammals, making them suitable for bone regeneration studies.
    • Zebrafish models offer advantages such as low cost, optical transparency, and rapid genetic manipulation.
    • The zebrafish model allows for reproducible and quick assessment of biomaterial biological properties.

    Conclusions:

    • Zebrafish present a powerful and efficient platform for the in vivo evaluation of novel biomaterials.
    • This model system facilitates rapid biological characterization for bone tissue engineering applications.
    • The use of zebrafish can accelerate the development and translation of new biomaterials.