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Related Concept Videos

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Commitment is the  process whereby stem cells:
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Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
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Stem cell quiescence: the challenging path to activation.

Noelia Urbán1, Tom H Cheung2,3,4

  • 1Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter Campus (VBC), Dr. Bohr Gasse 3, 1030 Vienna, Austria noelia.urban@imba.oeaw.ac.at tcheung@ust.hk.

Development (Cambridge, England)
|February 9, 2021
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Quiescence, a regulated cell cycle exit, is vital for adult stem cells. Understanding this state and its reactivation is key to improving tissue repair and function during aging.

Keywords:
Cell cycleDevelopmental biologyStem cells

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Area of Science:

  • Cell Biology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Quiescence is a reversible cell cycle exit, crucial for adult stem cell function.
  • Adult stem cells' quiescent state is essential for lifelong tissue homeostasis and regeneration.
  • Recent research reveals quiescence is an active, regulated process, not merely a dormant state.

Purpose of the Study:

  • To review the quiescent state in adult stem cells.
  • To discuss mechanisms of cell cycle entry from quiescence.
  • To highlight challenges and recent advances in studying stem cell quiescence.

Main Methods:

  • Literature review of recent studies on stem cell quiescence.
  • Analysis of regulatory mechanisms governing quiescent states.
  • Discussion of technical advancements in the field.

Main Results:

  • Quiescence is an actively regulated cellular state, not passive.
  • Adult stem cells in quiescence are responsive to external stimuli.
  • Reactivation of quiescent stem cells holds potential for anti-aging therapies.

Conclusions:

  • Understanding stem cell quiescence is critical for regenerative medicine.
  • Targeting quiescence pathways may enhance tissue repair and combat aging.
  • Future research should focus on overcoming current technical challenges in studying this state.