Related Experiment Video
Updated: Nov 18, 2025

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
Published on: September 16, 2020
Iris Manifestations in Inadequately Treated Chronic Recurrent Vogt-Koyanagi-Harada Disease
Soon-Phaik Chee1,2,3,4, May Zun Aung Win5,6
1Ocular Inflammation and Immunology Service, Singapore National Eye Centre, Singapore, Singapore.
Purpose:
To describe the iris changes in chronic recurrent Vogt-Koyanagi-Harada Disease (VKH).
Methods:
Retrospective case series. Clinical features of 3 VKH patients who developed bilateral depigmentation of the iris are described.
Results:
Patients had delayed diagnosis and inadequately treated chronic recurrent VKH. Patient 1 presented with bilateral multiple contiguous small granulomatous iris stromal lesions, severe diffuse iris swelling more severe near the iris root, producing peripheral iris undulations. Diffuse iris atrophy and peripheral depigmentation subsequently developed. Patient 2 presented with peripheral iris depigmentation, atrophy of the ciliary zone iris stroma and sparing of the sphincter pupillae, giving a 'sunflower appearance.' Patient 3 had extensive iris depigmentation, atrophy, and transillumination defects involving the entire iris.
Conclusion:
Uncontrolled bilateral diffuse granulomatous stromal iris inflammation leads to subsequent depigmentation, transillumination defects and atrophy, beginning in the peripheral iris. Sphincter pupillae is initially spared but complete iris atrophy may develop.
More Related Videos
Related Concept Videos
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Endocarditis II: Clinical Features of Infective Endocarditis
Rheumatic Heart Disease I: Introduction
Myocarditis I: Introduction
Chronic Kidney Disease II: Clinical Manifestations
Myocarditis II: Clinical Features and Diagnostic Tests

