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The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
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Related Experiment Video

Updated: Nov 18, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
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Interhemispheric transfer of working memories.

Scott L Brincat1, Jacob A Donoghue1, Meredith K Mahnke1

  • 1The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

Neuron
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Summary

Visual working memory (WM) seamlessly integrates information across brain hemispheres. Neural activity reveals memory traces transfer between hemispheres during saccades, demonstrating how brain dynamics create a unified visual working memory experience.

Keywords:
cognitioninterhemisphericneural synchronyprefrontal cortexworking memory

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Psychology

Background:

  • Visual working memory (WM) storage appears lateralized to specific cerebral hemispheres.
  • Despite hemispheric specialization, the subjective experience of WM is unified.

Purpose of the Study:

  • To investigate the neural mechanisms underlying the integration of visual working memory across hemifields.
  • To understand how memory traces are transferred and unified between cerebral hemispheres.

Main Methods:

  • Bilateral electrophysiological recordings from the lateral prefrontal cortex in humans.
  • Experimental manipulation involving instructed saccades to shift visual attention during WM tasks.
  • Analysis of neural activity, including spike rates, oscillatory power, and inter-hemispheric synchrony.

Main Results:

  • Hemispheric lateralization of memory traces inverted following saccade-induced shifts.
  • Transferred memory traces initially engaged distinct neural ensembles but converged over time.
  • Increased theta and beta frequency synchrony between hemispheres correlated with memory trace transfer.

Conclusions:

  • Neural dynamics between prefrontal hemispheres facilitate the integration of visual working memory across hemifields.
  • Hemispheric cooperation, particularly through synchronized oscillations, is crucial for a seamless WM experience.
  • This study provides insights into the neural basis of unified conscious perception from specialized brain regions.