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Anaphylaxis following "Hexabrix" during routine coronary angiography.
J A Langton1, P Magee, J Sedgwick
1Department of Cardiology, Westminster Hospital, London.
European Journal of Radiology
|February 1, 1988
Summary
Anaphylactic reactions to Hexabrix 320 radiographic contrast are rare. This case highlights a reaction despite pretreatment and continuous monitoring during coronary angiography.
Area of Science:
- Radiology
- Cardiology
- Allergy and Immunology
Background:
- Radiographic contrast media are essential for diagnostic imaging.
- Iopamidol (Hexabrix 320) is a non-ionic, low-osmolar contrast agent.
- Anaphylactic reactions to contrast media, though infrequent, are a known risk.
Observation:
- A patient undergoing coronary angiography experienced an anaphylactic reaction.
- The reaction occurred despite prophylactic administration of hydrocortisone and chlorpheniramine.
- Continuous monitoring was in place during the procedure.
Findings:
- The patient exhibited an anaphylactic reaction to Hexabrix 320.
- This event is considered rare, particularly in pretreated patients.
- The reaction underscores the unpredictable nature of hypersensitivity to contrast agents.
Implications:
- Clinicians should remain vigilant for adverse reactions to Hexabrix 320, even with pretreatment.
- This case may inform future protocols for contrast media administration and monitoring.
- Further research into the mechanisms of rare hypersensitivity reactions is warranted.