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Microbial Polyhydroxyalkanoates Granules: An Approach Targeting Biopolymer for Medical Applications and Developing
Moushmi Goswami1, Pavni Rekhi1, Mousumi Debnath1
1Department of Biosciences, Manipal University Jaipur, Rajasthan 303007, India.
Molecules (Basel, Switzerland)
|February 10, 2021
Summary
Polyhydroxyalkanoates (PHA) from Bacillus bacteria offer biodegradable bioplastics. Blending PHA with hydroxyapatite creates advanced nanocomposites for bone scaffolds and other demanding applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Microbiology
Background:
- Microbial polyhydroxyalkanoates (PHA) are biodegradable bioplastics produced by bacteria.
- Bacillus species are notable sources of short-chain and medium-chain length PHA.
- PHA exhibits desirable properties like biodegradability, thermostability, and mechanical strength.
Purpose of the Study:
- To review PHA as a sustainable biomaterial from bacterial sources.
- To explore PHA's application in fabricating bone scaffolds for tissue regeneration.
- To discuss strategies for utilizing PHA in advanced biomaterial applications.
Main Methods:
- Review of existing literature on PHA production and applications.
- Analysis of PHA blending with hydroxyapatite to form nanocomposites.
- Discussion of various fabrication methods for PHA-based bone scaffolds.
Main Results:
- PHA-hydroxyapatite nanocomposites show enhanced mechanical, thermal, and gas barrier properties.
- These nanocomposites offer potential for use in aggressive environments.
- PHA-based biocomposites are suitable for fabricating bone scaffolds via methods like electrospinning.
Conclusions:
- Polyhydroxyalkanoates from Bacillus represent a sustainable, eco-friendly biomaterial.
- PHA-hydroxyapatite nanocomposites offer superior properties for diverse industrial applications.
- PHA-based materials show significant promise for bone regeneration strategies.
