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Related Experiment Video

Updated: Nov 18, 2025

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Practical microcircuits for handheld acoustofluidics.

An Huang¹, William Connacher, Mark Stambaugh

¹Materials Science and Engineering Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. jfriend@ucsd.edu http://friend.ucsd.edu.

|February 10, 2021

Summary

This summary is machine-generated.

Researchers developed portable microcircuits to power acoustofluidic devices, enabling lab-on-a-chip and point-of-care applications. This breakthrough overcomes limitations of bulky electronics, paving the way for handheld diagnostic and therapeutic tools.

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Last Updated: Nov 18, 2025

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Published on: August 27, 2013

Area of Science:

Acoustofluidics
Microfluidics
Biomedical Engineering

Background:

Acoustofluidics utilizes ultrasonic transducers for fluid and particle manipulation in lab-on-a-chip devices.
Current acoustofluidic systems are limited by bulky, non-portable electronics.
This restricts their use in point-of-care and bedside applications.

Purpose of the Study:

To present a general process for creating portable, battery or mains-powered microcircuits for acoustofluidic devices.
To enable the development of handheld, point-of-care acoustofluidic technologies.
To overcome the limitations of traditional benchtop electronics in acoustofluidics.

Main Methods:

Detailed design strategy for microcircuits driving 1-300 MHz acoustic devices.
Identification of key circuit blocks and component selection.
Incorporation of automated resonance tracking, sensing, feedback, and adjustability.

Main Results:

Demonstration of a generalizable process for producing compact acoustofluidic drivers.
Successful integration of automated features for versatile device operation.
Examples of fluid and particle manipulation using the developed microcircuits.

Conclusions:

The developed microcircuits enable portable acoustofluidic devices, realizing the potential of lab-on-a-chip and point-of-care technologies.
This work empowers researchers to create handheld diagnostic and therapeutic tools.
Facilitates widespread adoption of acoustofluidics in clinical and research settings.