Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice.

Nature neuroscience·2026
Same author

Maternal-fetal type I interferon signaling drives TREM2 dysregulation and synaptic dysfunction in neurodevelopmental disorders.

Neuron·2026
Same author

Does inflammatory bowel disease play a role in cognitive decline? A systematic review.

Journal of Crohn's & colitis·2026
Same author

Autism subtypes identified using cross-species functional connectivity analyses.

Nature neuroscience·2026
Same author

Duloxetine ameliorates cerebral ischemic injury by inhibiting autophagy.

Autophagy·2026
Same author

An inflammatory fingerprint in mild cognitively impaired patients is reversed by physical and cognitive training.

Brain, behavior, & immunity - health·2025

Related Experiment Video

Updated: Nov 18, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.1K

Feeling depressed? Keep calm, and watch microglia.

Michela Matteoli1, Davide Pozzi2

  • 1Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy; CNR Institute of Neuroscience, Milano, Italy.

Immunity
|February 10, 2021
PubMed
Summary

Brain immune cells, microglia, activate an IL-6 loop in the striatum. This triggers prostaglandins, causing negative affective states by stimulating specific neurons.

More Related Videos

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.4K
Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders
06:12

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders

Published on: September 6, 2024

1.7K

Related Experiment Videos

Last Updated: Nov 18, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.1K
Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.4K
Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders
06:12

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders

Published on: September 6, 2024

1.7K

Area of Science:

  • Neuroimmunology
  • Affective Neuroscience

Background:

  • The brain's immune system, involving microglia and signaling molecules, actively influences neural function.
  • Understanding the precise mechanisms linking immune activity to brain states is crucial.

Purpose of the Study:

  • To investigate how microglia activation in the striatum impacts affective states.
  • To elucidate the molecular pathways involved in immune-mediated regulation of brain activity.

Main Methods:

  • Utilized mouse models to study microglia activation in the striatum.
  • Analyzed the roles of Interleukin-6 (IL-6) and prostaglandins in affective state regulation.

Main Results:

  • Microglia activation in the striatum initiates an Interleukin-6 (IL-6) autocrine signaling pathway.
  • This IL-6 loop leads to prostaglandin release.
  • Prostaglandins stimulate medium spiny neurons, inducing a negative affective state.

Conclusions:

  • Microglial activation in the striatum can directly drive negative affective states through an IL-6 and prostaglandin-dependent mechanism.
  • This study highlights a novel pathway for immune system regulation of mood and behavior.